We research the different stages of cognitive aging preceding Alzhiemer's disease (e.g. typical aging, preclinical Alzheimer's, and mild cognitive impairment) to investigate cognitive strategies and interventions that may delay age- and neuropathology-related cognitive decline.
Computational modeling of cognitive and neural profiles in cognitive aging
We apply state-of-the-art neuroimaging, statistical, and computational modeling techniques to understand the variability in cognitive trajectories and neural patterns across typical and atypical aging processes to better understand neuroprotective factors that play a role in promoting successful aging.
Adaptation capacity and the role of central-peripheral nervous system interactions in neuroplasticity
We examine the interaction between the central nervous and peripheral homeostatic systems to understand the role of this relationship in neuroplasticity. This, in turn,
We use non-pharmacological cognitive interventions with physiological techniques, such as electrocardiography and transcranial direct current stimulation, to evaluate changes in brain and cognitive plasticity in older adults with different levels of cognitive function.
Neurophysiological markers of brain aging and neuropathological profiles
In addition to standard neuropsychological assessments, we employ multimodal neuroimaging techniques to investigate changes in brain function and structure associated with aging and Alzheimer's neuropathology.
Cognitive aging-associated phenomenons
We investigate the impact of age on cognitive and physical phenomenons of wellbeing, including fatigue, frailty, social isolation, and decision-making, and the implications these domains have on functional independence in older adults.