Lab Focuses

Delaying cognitive and functional decline

 

We research the stages of cognitive decline preceding Alzheimer's type dementia (e.g. preclinical Alzheimer's, mild cognitive impairment, and preclinical Alzheimer's) to investigate

strategies that may delay 

age- and pathology-related cognitive decline.

Neurophysiological markers

 

Beyond the traditional neuropsychological tests, we employ multiple imaging techniques to measure brain function and structure (e.g., T1, BOLD fMRI, diffusion tensor imaging) and brain pathology (e.g., FDG and amyloid PET).

Computerized intervention

 

We utilize different computer (e.g., MATLAB, Python) and physiological (e.g., non-invasive brain stimulation, ECG-related neuro-feedback) programming tools to optimize the effect of cognitive intervention on older adults with various cognitive capacities.

Central-peripheral interaction

 

We examine the interaction between the central nervous system and peripheral homeostatic systems to understand the impact of these relationships on neural plasticity.

Computational modeling of cognitive and neural profiles in aging

 

We apply different statistical and computational modeling techniques to understand the complicated cognitive trajectories and neural patterns in normal and abnormal aging process.