Computerized Cognitive Training

Research background

This project seeks to identify neural changes that occur in adults with mild cognitive impairment (MCI) after engagement in computerized cognitive training. Individuals with MCI are at high risk for Alzheimer’s disease (AD). Understanding how cognitive training can protect cognitive function in MCI can contribute to the development of effective interventions to delay AD in individuals at risk, thereby reducing the significant morbidity and health care costs associated with AD.

Training paradigms

Here are some examples of computerized cognitive training paradigms used in different populations. All of these training paradigms emphasize response time to visual stimuli.


(P. Ren, 2015)


(K. Fhinger, 2015)


(K. Schneider, 2002)

Neuroplasticity and brain networks

Assessing brain changes is important to determine whether  computerized cognitive training can produce a sustainable positive effect on older adults' cognitive function.


The central executive network (CEN) and default mode network (DMN) are two neural networks critical for maintaining different aspects of cognitive function and susceptible to both normal and abnormal aging processes, including MCI (Figure 1). In our training project, we are not only interested in the improvements of cognitive performance, but also the underlying mechanism (i.e. neuroplasticity) of the training effect that may recover or enhance these brain functions. We use different magnetic resonance imaging (MRI) techniques to assess the function and structure of these neural networks, thereby evaluating whether our cognitive training paradigms promote neuroplasticity.



Figure 1. Brain "glass plots" of functional connectivity associated with the central executive network (CEN, top) and default mode network (DMN, bottom).