The organization of brain networks plays an important role in understanding neural mechanisms involved in the development and prevention of Alzheimer’s disease. Diffusion magnetic resonance imaging is a standard neuroimaging technique used to understand how neurons connect to each other across different brain regions (referred to as brain connectome). However, diffusion MRI is highly sensitive to motion artifacts, which introduces noise to the data and reduces image quality. High resolution diffusion MRI requires longer scan times for high image resolution, while shorter scan times reduce image quality. This trade-off between spatial and temporal quality is particularly challenging for patients with different cognitive statuses who may experience anxiety during longer scan sessions. Long scanning sessions also increase the likelihood of noisy data because it can be challenging for patients to remain still for an extended period. BIS story aims to address these limitations by examining whether different diffusion MRI scanning parameters are suitable for collecting dMRI in less time without comprising image resolution.
Identify suitable diffusion MRI scanning parameters that allow high-resolution diffusion MRI data to be collected in less time compared to standard techniques.
BIS study is recruiting adults ages 60-89 years old who have noticed changes in their memory OR have a clinical diagnosis of mild cognitive impairment. BIS is a short-term study that be completed in 1-2 weeks and involves
1 cognitive assessment involving memory and thinking
2 fMRI brain scans
1 blood draw
Participants will be paid up to $100 for completion of all study measures.
COVID Procedures: We follow all NY state and University of Rochester Medical Center guidelines to ensure your and our staff's safety. A mask is required at all times when inside our facilities. We will conduct screening questionnaires and perform temperature checks upon your arrival and escort to our lab. All staff are screened daily and wear personal protective equipment (i.e., gloves, mask, face shield) during study visits. The number of staff and visitors to our lab is limited to those essential for in-person activities, and all interview rooms and equipment are disinfected regularly, as well as before and after each participant's appointment.